The Mass Effect franchise is carved into the Mount Rushmore of video game RPGs, remaining relevant after nearly a decade of no releases, and weathering the disastrous launch of Mass Effect: Andromeda. This is because the original Mass Effect trilogy is so replayable thanks to solid fundamentals and a deep, interconnected matrix of player choices that can lead to radically distinct experiences between playthroughs.




Having said that, even the most dedicated Mass Effect fans will probably find the trilogy a bit stale after so many standard runs. Luckily, the gameplay and narrative structure of Mass Effect allow for a number of unique challenge playthroughs, as creative and vigilant players can implement their own restrictions for a fresh journey through the trilogy. Like with anything, some of these custom challenges are better than others.

All the following challenges are designed to be playable in the vanilla version of
Mass Effect
. In other words, this tier list won’t include any challenge runs that require the use of mods.

S-Tier Mass Effect Challenge Runs


Simple Yet Effective Ways to Modify Mass Effect

  • Vanilla Insanity Run
  • No-Gun Run

The two most obvious Mass Effect challenge runs are also the best options for players looking to tweak their repeated playthroughs. A basic run on Mass Effect‘s Insanity difficulty is the first type of challenge that veteran players need to get out of the way, as it dramatically changes how they interface with combat. While it’s typically optional to do things like directing squadmates and manually activating their abilities on lower difficulties, it’s virtually required on Insanity. Indeed, the strategic depth of Mass Effect‘s combat shines through on its highest difficulty, making for a tough playthrough that’s arguably the best way to enjoy the game.

Insanity difficulty can also be used to modify any of the following challenge runs, making them even more difficult and complex.


An easy next step for players looking to move beyond a simple Insanity run is the no-guns playthrough. The best class for this challenge is Adept because of their affinity for biotic powers, but any class will work. This, of course, dramatically changes how the game feels at just about every moment, and the fact that it can be considerably different depending on the class the player chooses gives it a lot of variety within itself. Committing to not using guns in favor of abilities can keep Mass Effect players busy for quite some time indeed.

A-Tier Mass Effect Challenge Runs

Making Mass Effect a Bit Stranger

  • No-Death Insanity Run
  • Coward Shepard Run
  • Boring Shepard Run


A No-Death Insanity Run is self-explanatory, and one of the most brutally difficult ways to engage with Mass Effect. Getting through the entirety of the original trilogy on Insanity without dying a single time is certainly a satisfying achievement, but it will be a borderline impossible task for anyone who isn’t already intimately familiar with the franchise. Starting a playthrough over after a single death, especially if someone wants to fully commit and treat the whole trilogy as one playthrough, means that this challenge run has the potential to be particularly frustrating.

The other two challenge runs in this tier are much easier, and probably a bit more enjoyable as well. For a Coward Shepard Run, players will have to make full use of Mass Effect‘s squad abilities and commanding mechanics, not firing a single shot or using any abilities as Shepard. This run requires players to take a more tactical approach while focusing purely on evasion, keeping Shepard out of harm’s way while their squadmates do the heavy lifting.


The Boring Shepard Run is far less focused on changes to combat. Rather, this challenge run simply requires that players not use any Paragon/Charm or Renegade/Intimidate dialog options, which can lock them out of certain benefits and force them into conflicts that could have been otherwise avoided by talking things out. This lack of commitment to Mass Effect‘s choice system can make the game both more challenging and considerably unique, as most players will opt to make at least some tough calls throughout their regular playthroughs.

B-Tier Mass Effect Challenge Runs

Decent, Weird Takes on Mass Effect

  • Racist Shepard Run
  • Mass Death Run
  • Gun-Only Run


There are a number of unique alien races in the world of Mass Effect, which is part of what makes it so dense and alluring. However, this interplanetary mixing doesn’t always go over so well, as there are a number of characters in the franchise, such as Ashley Williams in Mass Effect 1, who are prejudiced and xenophobic toward sentient beings not of their same species. The “Racist” Shepard Run requires players to assume this role, never taking alien companions along on missions, never commiserating with them or completing their loyalty missions, and always agreeing with anti-alien sentiment. This makes the game harder, and it’s an interesting role-playing experience, but it also locks players out from some of the best gameplay and narrative content in the series.


In a similar vein is the Mass Death Run, AKA the Filling Up the Memorial Run. In this playthrough, players must intentionally cause or allow the deaths of Mass Effect NPCs, getting as many names on the Normandy death memorial as possible. This requires getting the worst ending to Mass Effect 2, and playing Mass Effect 3 with a number of important characters missing. Getting all possible deaths is actually surprisingly challenging, but it’s also a bit of a depressing way to play the games, making it not suitable for those looking to have a more lighthearted experience.

Finally, there is the Gun-Only Run, which is self-explanatory: no biotics, no grenades, no special abilities allowed—only firearms. Players can take this challenge run to the next level by only taking Mass Effect‘s soldier companions along with them on missions, totally locking themselves out from biotics and tech abilities. This is definitely a unique way to play, but it also means reducing Mass Effect to a more by-the-numbers cover shooter, so it’s not for everyone.

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